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Authors Xiao YF, Li JM, Wang SM, Yong X, Tang B, Jie MM, Dong H, Yang XC, Yang SM
Received 5 January 2016
Accepted for publication 15 March 2016
Published 15 July 2016 Volume 2016:11 Pages 3023—3034
DOI https://dx.doi.org/10.2147/IJN.S103648
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Alexander Kharlamov
Peer reviewer comments 2
Editor who approved publication: Dr Lei Yang
Abstract: Gastric cancer is one of the leading causes of tumor-related deaths in
the world. Current treatment options do not satisfy doctors and patients, and
new therapies are therefore needed. Cerium oxide nanoparticles (CNPs) have been
studied as a potential therapeutic approach for treating many diseases.
However, their effects on human gastric cancer are currently unknown.
Therefore, in this study, we aimed to characterize the effects of CNPs on human
gastric cancer cell lines (MKN28 and BGC823). Gastric cancer cells were
cocultured with different concentrations of CNPs, and proliferation and
migration were measured both in vitro and in vivo. We found that CNPs inhibited
the migration of gastric cancer cells when applied at different concentrations,
but only a relatively high concentration (10 µg/mL) of CNPs suppressed
proliferation. Furthermore, we found that CNPs increased the expression of
DHX15 and its downstream signaling pathways. We therefore provide evidence
showing that CNPs may be a promising approach to suppress malignant activity of
gastric cancer by increasing the expression of DHX15.
Keywords: cerium oxide nanoparticles, gastric
cancer, DHX15, p38