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已发表论文

共轭的树枝状聚合物及超声波介导的透皮双氯芬酸 (Diclofenac) 药物输送系统

 

Authors Huang B, Dong WJ, Yang GY, Wang W, Ji CH, Zhou FN

Published Date July 2015 Volume 2015:9 Pages 3867—3876

DOI http://dx.doi.org/10.2147/DDDT.S75702

Received 11 October 2014, Accepted 1 December 2014, Published 23 July 2015

Abstract: The purpose of the present study was to develop a novel transdermal drug-delivery system comprising a polyamidoamine dendrimer coupled with sonophoresis to enhance the permeation of diclofenac (DF) through the skin. The novel transdermal drug-delivery system was developed by using a statistical Plackett–Burman design. Hairless male Wistar rat skin was used for the DF-permeation study. Coupling media concentration, ultrasound-application time, duty cycle, distance from probe to skin, and a third-generation polyamidoamine-dendrimer concentration were selected as independent variables, while in vitro drug release was selected as a dependent variable. Independent variables were found to be statistically significant (<0.05). DF gel without dendrimer and ultrasound treatment to skin (passive delivery, run 13) showed 56.69 µg/cm2 cumulative drug permeated through the skin, while the DF-dendrimer gel without sonophoresis treatment (run 14) showed 257.3 µg/cm2 cumulative drug permeated through the skin after 24 hours. However, when the same gel was applied to sonophoresis-treated skin, drastic permeation enhancement was observed. In the case of run 3, the cumulative drug that permeated through the skin was 935.21 µg/cm2. It was concluded that dendrimer-coupled sonophoresis-mediated transdermal drug delivery system has the potential to enhance the permeation of DF through the skin.
Keywords: sonophoresis, ultrasound, polyamidoamine, permeation enhancers, stratum corneum